Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Oct 21, 2022

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

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Video: Genetics Behind Swine Resilience - Dr. Jenelle Dunkelberger

In this episode of The Swine it Podcast Show Canada, Dr. Jenelle Dunkelberger, geneticist at Topigs Norsvin, explains how genetics can improve disease resilience in pigs. She explores how resilience differs from resistance, the role of genetic variation, and how breeding strategies can enhance health and performance under disease pressure. Dr. Dunkelberger also covers practical applications and future implications for swine production. Listen now on all major platforms!

"Controlled experimental trials confirm that differences in mortality and performance under disease pressure are linked to genetic background, even when environmental conditions remain consistent."

Meet the guest: Dr. Jenelle Dunkelberger / jenelle-dunkelberger-9200ab86 is a geneticist at Topigs Norsvin, where she leads the Global Health and Behavior Research Platform. She earned her PhD from Iowa State University, focusing on host genetics and disease response in pigs. Her work centers on improving swine health and performance through genetic selection for resilience and behavior traits.