Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Oct 21, 2022

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

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Video: The Next Pork Disease Outbreak? How Biosecurity Can Stop It Before It Starts!

The threat of disease outbreaks remains one of the biggest challenges facing pork producers across North America. At the World Pork Expo, I spoke with Rob Hannam, CEO of Farm Health Guardian, to discuss why biosecurity is more critical than ever and how innovative technology is helping producers reduce risk before disease reaches the farm.
In this interview, Rob explains how Farm Health Guardian's advanced biosecurity platform helps pork operations monitor and manage visitor access, track potential disease exposure pathways, and strengthen on-farm biosecurity protocols. With recent outbreaks of diseases such as ASF, PRRS, PED and others continuing to impact global pork production and ongoing concerns surrounding the spread of endemic diseases, proactive prevention measures have become essential for protecting herd health and business continuity.
Learn how digital biosecurity tools can help producers identify risks, improve compliance, and create stronger defenses against costly disease outbreaks. Discover why leading pork operations are adopting technology-driven biosecurity solutions to safeguard animals, employees, and the future of the industry.