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Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

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We Let Dad Drive a 50,000 Pound Dump Truck

Video: We Let Dad Drive a 50,000 Pound Dump Truck



There's old hog barns under that field now. The old hog barn site on the farm has been sitting there for decades, and this is the week it finally came out: concrete pad, burn pile, charred lumber, all of it loaded into a CAT 725C rock truck and buried in a pit we dug back in the timber.

Tork's been waiting his whole life to drive one of these, so he gets the keys to a 50,000 pound rock truck and I ride shotgun. The excavator loads, the dozer clears the timber, the drone shows the whole site from above, and by sundown there's nothing left of the old place but a smooth patch of dirt. It's a weird feeling erasing something that was here before either of us, but the farm has to keep moving.