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Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

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Managing Severe PRRS Outbreaks - Dr. Claire Mtezankuni

Video: Managing Severe PRRS Outbreaks - Dr. Claire Mtezankuni



In this episode of The Swine it Podcast Show Canada, Dr. Claire Mtezankuni, Swine Veterinarian at Carthage Veterinary Service, discusses the growing severity of PRRS outbreaks in sow farms. She explains how respiratory disease and sow mortality are changing outbreak response, why necropsies and bacterial cultures can guide treatment, and how vaccination, biosecurity, pain management, and clear team communication support recovery and elimination. Listen now on all major platforms!

“Emerging PRRS strains can produce severe reproductive and respiratory disease simultaneously, creating substantial health challenges across sow farms during acute outbreaks.”

Meet the guest: Dr. Claire Mtezankuni / claire-mtezankuni-2529b1b3 is a Swine Veterinarian at Carthage Veterinary Service in Illinois, where her work includes commercial farm veterinary leadership, herd health, disease elimination, and veterinary internship coordination. She holds a DVM from the University of Wisconsin–Madison and a Master of Veterinary Science in Livestock Systems Health from the University of Illinois Urbana-Champaign. Learn more from Dr. Claire Mtezankuni on The Swine it Podcast Show Canada, available on all major platforms.