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Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Abstract: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

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Season 7, Episode 4: Using Data to Better Manage PRRSV

Video: Season 7, Episode 4: Using Data to Better Manage PRRSV

PRRS continues to be one of the biggest challenges facing pork producers, but each outbreak can also provide valuable information about herd recovery, losses and the management decisions that follow.In this episode, Dr. Ana Paula Serafini Poeta Silva, a research scientist at Iowa State University, discusses the PRRS Outbreak Management Program, or POMP, and what researchers have learned from a database containing information from more than 700 breeding-herd outbreaks. She explains how POMP uses data from individual outbreaks to establish benchmarks producers can use to better understand what to expect during recovery, including potential losses and the time it may take for a herd to return to baseline production. The conversation also explores how PRRS management has evolved, including the role of live virus inoculation and modified-live vaccines.