Abstract: Estimating Transmission Dynamics of African Swine Fever Virus from Experimental Studies

Jan 09, 2023

Abstract: Estimating transmission dynamics of African swine fever virus from experimental studies

African swine fever virus (ASFV) continues to spread across the world, and currently, there are no treatments or vaccines available to combat this virus. Reliable estimates of transmission parameters for ASFV are therefore needed to establish effective contingency plans. This study used data from controlled ASFV inoculations of pigs to assess the transmission parameters. Three models were developed with (binary, piecewise-linear and exponential) time-dependent levels of infectiousness based on latency periods of 3-5 days derived from the analysis of 294 ethylenediamine tetraacetic acid-stabilized blood samples originating from 16 pigs with direct and 10 pigs with indirect contact to 8 inoculated pigs. The models were evaluated for three different discrete latency periods of infection. The likelihood ratio test showed that a binary model had an equally good fit for a latency period of 4 or 5 days as the piecewise-linear and exponential model. However, for a latency period of 3 days, the piecewise-linear and exponential models had the best fit.

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Video: Managing Severe PRRS Outbreaks - Dr. Claire Mtezankuni

In this episode of The Swine it Podcast Show Canada, Dr. Claire Mtezankuni, Swine Veterinarian at Carthage Veterinary Service, discusses the growing severity of PRRS outbreaks in sow farms. She explains how respiratory disease and sow mortality are changing outbreak response, why necropsies and bacterial cultures can guide treatment, and how vaccination, biosecurity, pain management, and clear team communication support recovery and elimination. Listen now on all major platforms!

“Emerging PRRS strains can produce severe reproductive and respiratory disease simultaneously, creating substantial health challenges across sow farms during acute outbreaks.”

Meet the guest: Dr. Claire Mtezankuni / claire-mtezankuni-2529b1b3 is a Swine Veterinarian at Carthage Veterinary Service in Illinois, where her work includes commercial farm veterinary leadership, herd health, disease elimination, and veterinary internship coordination. She holds a DVM from the University of Wisconsin–Madison and a Master of Veterinary Science in Livestock Systems Health from the University of Illinois Urbana-Champaign. Learn more from Dr. Claire Mtezankuni on The Swine it Podcast Show Canada, available on all major platforms.