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Genetic Breakthrough May Control Africa's East Coast Fever, Which Kills A Million Cattle A Year

Genetic Breakthrough May Control Africa's East Coast Fever, Which Kills A Million Cattle A Year

A serendipitous discovery has led researchers from the International Livestock Research Institute (ILRI) in Kenya and the Roslin Institute at the University of Edinburgh in Scotland to identify a genetic marker that accurately predicts whether an individual cow is likely to survive infection with East Coast fever—making possible breeding programs that could improve the livelihoods of millions of smallholder farmers.

The severe cattle disease East Coast fever is caused by the Theileria parva parasite and transmitted by ticks, causing a kind of leukemia. It kills a million animals a year in the 13 African countries where it is endemic—that's one cow every 30 seconds. Those losses cost an estimated US$300 million annually, and can devastate the livelihoods of smallholder farmers.

"If the cattle are susceptible, without treatment you can lose 100% of your herd in two or three weeks," says ILRI's Phil Toye. Because it doesn't affect wealthy countries, there has historically been limited funding for research into the disease.

A vaccine for East Coast fever exists and usually gives cattle lifelong immunity. However, making it is time-consuming, and it costs ten to twenty times more than other common livestock vaccines (it involves making a kind of "tick smoothie" by crushing up hundreds of thousands of infected ticks in an industrial blender).

The other option is regularly dipping animals in acaricides—pesticides that kill ticks—but this is also labor-intensive, polluting, and in some places farmers have to dip their cows more than once a week. "We're struggling to control this disease," says Toye.

In 2013, an ILRI-Roslin team conducted an experiment at Ol Pejeta Conservancy in Kenya to test how well the vaccine worked when indigenous cattle grazed near buffalo, which also carry a form of East Coast fever. Out of twelve vaccinated animals, nine of them died from the disease.

Nine of the twelve unvaccinated control animals died too. Tatjana Sitt, a post-doctoral scientist working on the project, just happened to check their pedigree. "She saw that the three ones that survived all had the same sire," says Toye. "We thought, is that just a fluke? Or is this something that's really worth following up? It turned out to be a very serendipitous observation."

The sire in question—a muscular and prolific specimen of a Boran bull (Bos indicus) dubbed 3167—died just after the discovery was made. But in a follow-up field trial, 12 out of 15 of Bull 3167's offspring survived East Coast fever, while all 10 of the unrelated control animals died.

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CEOs of the Industry – Rob Brenneman, CEO of Brenneman Pork

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“From Pork Production to Performance Nutrition: A Candid Conversation with One of the Industry’s Most Unconventional Thinkers”

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Rob shares how a deep-rooted commitment to **health—both animal and personal—**drives his philosophy and decision-making. From reshaping pork nutrition and advocating for the return of well-marbled, flavorful pork to confronting the ongoing battle with PRRS and other health threats, Rob’s insights reflect decades of hands-on experience and bold innovation.

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Well-Marbled Pork as Premium Protein: The science, consumer insights, and culinary feedback behind Rob’s mission to reintroduce pork as a premium, flavorful protein.

Sustainability & Farm Culture: How Brenneman Pork balances environmental responsibility with day-to-day positivity and resilience.

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Whether you're a producer, nutritionist, policymaker, or future leader, this episode offers a masterclass in where pork production is headed—and how visionaries like Rob are shaping it.