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How Can Nutrition Prevent E. coli in Weaned Pigs?

Post-weaning diarrhea (PWD) is generally defined as loose, watery stool occurring in the first 14 days after weaning. The incidence of PWD is multi-faceted, but often results from exposure to infectious pathogens such as rotavirus, Salmonella or Escherichia coli (E. coli). Sensitivity to PWD is also affected by physiological and metabolic changes of the gastrointestinal (GI) system that occur at the time of weaning, leaving the newly weaned pig more vulnerable to enteric disease outbreaks. Here are four ways nutrition can help.

DIETARY ZINC AND COPPER
To prevent pathogen induced diarrhea in weanling pigs, pharmacological levels of zinc (2,000 to 3,000 ppm) from zinc oxide (ZnO) are commonly fed for the first 2 to 3 weeks after weaning. The mode of action of ZnO is not well understood; however, several different mechanisms related to immune system modulation, nutrient absorption and preservation of intestinal morphology have been identified. Copper is another mineral that can be fed to prevent pathogen induced diarrhea. However, pharmacological levels of copper (125 to 250 ppm) from copper sulfate or tribasic copper chloride generally aren’t fed until late nursery. Unfortunately, these feeding practices have led to increased environmental concerns and issues surrounding bacterial resistance. This emphasizes the need to evaluate alternative feeding strategies for the prevention and management of enteric disease, specifically E. coli.

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PRRS Eradication Strategies - Dr. DeBuse and Dr. Tousignant

Video: PRRS Eradication Strategies - Dr. DeBuse and Dr. Tousignant


In this episode of The Swine it Podcast Show, Dr. Neil DeBuse from Kalmbach Feeds and Dr. Steve Tousignant from Vaxxinova US discuss PRRS management strategies, recombination risks, whole genome sequencing, and the role of autogenous immunization programs in swine systems. They highlight practical approaches to improving immunity, reducing outbreaks, and advancing PRRS control across production systems. Listen now on all major platforms!

"Being PRRS negative sooner is a real key for eradication because every additional positive week increases production losses and viral exposure risks." - Dr. Neil DeBuse

Meet the guest: Dr. Neil DeBuse is a veterinarian at Kalmbach Feeds with more than 30 years of experience in swine health and production. His work focuses on PRRS control, biosecurity, immunity, and improving production stability across commercial swine systems in the United States and internationally.

Dr. Steve Tousignant is Director of the Swine Business Unit and Technical Services Veterinarian at Vaxxinova US, with a DVM and PhD from the University of Minnesota. His experience combines epidemiology, technical services, and practical immunization strategies designed to support consistent herd performance and long-term production stability. Don’t miss the chance to be part of the Swine Inner Circle!