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NTU Singapore and Temasek Polytechnic Scientists Replace Fishmeal in Aquaculture With Microbial Protein Derived From Soybean Processing Wastewater

Scientists from Nanyang Technological University, Singapore (NTU Singapore) and Temasek Polytechnic have successfully replaced half of the fishmeal protein in the diets of farmed Asian seabass with a ‘single cell protein’ cultivated from microbes in soybean processing wastewater, paving the way for more sustainable fish farming practices.

The use of a cultivated protein is new to aquaculture production, say the scientists from the Singapore Centre for Environmental Life Sciences Engineering (SCELSE) leading NTU’s efforts in the study, and Temasek Polytechnic’s Aquaculture Innovation Centre (AIC).

Farmed aquaculture species rely heavily on feed made from wild-caught fish, known as fishmeal, which is not sustainable and contributes to overfishing of the seas.

Single cell protein, a sustainable alternative, can be cultivated from food processing wastewater. In particular, the wastewater from soybean processing contains organisms with probiotic potential that are essential for healthy fish growth.

Wastewaters from the food-processing industry are free of pathogens and other contaminants, make them suitable for growing microbes. Normally after processing the wastewater is discharged and flows into a wastewater reclamation plant. Its nutrients are not recovered, resulting in a lost opportunity to maximise resource use.

Co-lead author of the study, Dr Ezequiel Santillan, senior research fellow at SCELSE, said, “Our study represents a significant step forward in sustainable aquaculture practices. By harnessing microbial communities from soybean processing wastewater, we have demonstrated the feasibility of producing single cell protein as a viable alternative protein replacement in fish feed, reducing the reliance on fishmeal and contributing to the sustainability of the aquaculture industry.”

The joint research team said that their waste-to-resource approach tackles food security and waste reduction, supporting the development of a circular economy with zero waste as outlined in the United Nations Paris Agreement.

The study, published in the peer-reviewed science journal Scientific Reports, aligns with the University's research pillar of NTU 2025, a five-year strategic plan that aims to leverage innovative research to mitigate human impact on the environment.

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