Phylogenetic Analysis of Porcine Circovirus 3 Circulating in Canadian Pigs

Jun 24, 2022

Abstract: Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs

Introduction: Porcine circovirus 3 (PCV3) has been detected in pigs worldwide and associated with several clinical signs.
Methods: To investigate the genetic diversity of PCV3 strains circulating in Canada, 44 PCV3 positive samples from Saskatchewan (2/44), Manitoba (2/44), Quebec (4/44), Alberta (11/44) and Ontario (25/44) submitted to diagnostic laboratories in Canada between 2019 and 2021 were sequenced and analyzed.
Results: Phylogenetic analysis of capsid genes showed that all of the 44 Canadian strains classified into PCV3a and segregated into seven lineages with common amino acid changes observed at A24V, R27K, N56D, T77S, Q98R, L150I (F) and R168K positions.

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Video: Genetic Resistance to Post-Weaning Diarrhea - Dr. Vahab Farzan

In this episode of The Swine it Podcast Show, Dr. Vahab Farzan from the University of Guelph explains why post-weaning diarrhea remains a major challenge for swine production. He discusses genetics, gut microorganisms, immunity, diagnostics, and targeted vaccination strategies to improve disease prevention. Listen now on all major platforms!

“Some pigs are genetically resistant to pathogenic E. coli because they lack the specific receptors required for bacterial attachment.”

Meet the guest: Dr. Vahab Farzan / vahab-farzan-b076445 is a Research Scientist, Adjunct Professor, and Associated Graduate Faculty at the University of Guelph. With a DVM, MSc, and PhD, Dr. Farzan's research focuses on infectious diseases in swine, including bacterial pathogens, gut microorganisms, epidemiology, and strategies to improve animal health. Learn more from Dr. Vahab Farzan on The Swine it Podcast Show, available on all major platforms.