Twenty Years of Enriching Diets With Biofortification

It is an important year for biofortification: 2023 will mark the 20th anniversary of this nutrition-agricultural innovation, for which its pioneers were awarded the World Food Prize.

More than three billion people around the world, mostly in Africa, Asia, and Latin America, cannot afford a nourishing, diverse diet that provides enough vitamins and minerals (micronutrients). While efforts to pursue dietary diversity—the accepted gold standard for optimal health—must continue, a healthy diet remains out of reach for a vast majority of the world’s population.

The consequences are dire. A staggering two billion people get so little essential micronutrients from their diets that they suffer from “hidden hunger”, the often-invisible scourge of micronutrient malnutrition.

To combat hidden hunger requires a range of context-specific combinations of evidence-based interventions that complement each other, including dietary diversification, supplementation, commercial food fortification, biofortification, and public health measures (like safe water, sanitation, and breastfeeding).

CGIAR transdisciplinary, participatory, and action-oriented research and innovations to improve nutritional outcomes, including biofortification, are making a vital contribution towards realizing Sustainable Development Goal 2 to end hunger and all forms of malnutrition.

Meeting Nutritional Needs

Biofortified crops are targeted mostly at rural food systems in LMICs, where deficiencies in vitamin A, iron, and zinc are highly prevalent. Young children, adolescent girls, and women are the priority groups for biofortification because their relatively high micronutrient needs predispose them to hidden hunger.

The scientific body of evidence supporting biofortification spans over two decades. Each biofortified crop is the subject of extensive research to evaluate its intrinsic nutritional value and its potential impacts on human nutrition and health.

Vitamin A orange sweet potato (OSP) was the first biofortified staple to be delivered at scale and evaluated in sub-Saharan Africa, a joint effort by HarvestPlus, the International Potato Center, and the International Food Policy Research Institute. It has very high levels of vitamin A (traditional white varieties contain none) and long-term studies indicate it can help reduce diarrhea in children and is a cost-effective way to improve population vitamin A intake, thereby improving child and maternal health and reducing the likelihood of vitamin A deficiency. Breeding efforts are now simultaneously increasing the iron content of OSP, to deliver more of multiple stacked micronutrients.

Evidence from additional randomized controlled trials have demonstrated that nutrient-enhanced staple crops generate positive direct and indirect health effects on multiple age groups, for example:

• Zinc wheat decreased common infections in women and their children in India, thus potentially reducing health care costs and freeing up mothers’ time for childcare and other productive endeavors.
• Zinc rice improved linear growth in Bangladeshi children under three years old, which may contribute to reducing stunting and its attributable impact on cognitive and physical performance.
• Iron beans and pearl millet improved cognitive performance and physical work efficiency among school-age children and university students—functions essential for good health and a productive life.
• Vitamin A maize and vitamin A cassava have improved the vitamin A status of children. Vitamin A maize improved visual adaptation to dim-light conditions, with clear implications on multiple aspects of children’s safety and livelihoods. It also increased the vitamin A content of breast milk, which protects breastfed children against enteral infections.

Supplementation studies have clearly shown that improvements in micronutrient status, particularly zinc, vitamin A, and iron status, generate improvements in immunity, growth, and multiple other dimensions of good health. The improvements are not specific to how the micronutrients are delivered (e.g., by food or pills), but rather due to positive changes in nutritional status.

Global Benefit

The number of vulnerable rural families and communities growing and benefiting from nutrient-enriched crops has significantly increased year over year. Today, over 86 million people in farming households are eating biofortified foods—progressing rapidly towards 100 million in later 2023.

Eliminating malnutrition requires multiple solutions, and biofortification is an extremely important part of CGIAR’s efforts in pursuit of this goal.

Research has proven biofortification to be an efficacious, cost-effective, and scalable innovation that can play a pivotal role in transforming food systems to deliver affordable and accessible nutritious food for all.