Unique Structure Of African Swine Fever Virus Enzyme May Allow Drug Development

Mar 01, 2017

A DNA-copying protein from a lethal pig virus has a unique structure that may offer a target for drugs designed to combat this important agricultural disease, according to a study publishing February 28th in the open-access journal PLOS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China.

African swine fever virus (ASFV) is a highly contagious and deadly disease in pigs that has spread from Africa to areas of Europe and Asia. Currently there are no treatments, and control relies on killing entire herds once infection is detected. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, but the structure of this enzyme has not been determined in detail. Here, the authors used X-ray diffraction and nuclear magnetic resonance to solve the structure at atomic resolution.

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Video: You Be The Judge: Evaluating 8 Breeding Rams!

It's time for some honest feedback here at Ewetopia Farms! Today, we’re showing you all eight rams we used for breeding this year. Instead of just presenting them, we thought it would be fun to create a “Ram Report Card” — where we point out both their strengths and areas for improvement.

But here’s the twist: you be the judge! In the comments, let us know what you like about each ram and what you think could be improved. No ram is ever perfect, but every one of them brings something valuable to the flock. By sharing perspectives, we all learn more about what to look for in good breeding stock.

At Ewetopia Farms, we raise registered Suffolk and Polled Dorset sheep, focusing on high-quality genetics, structure, and friendly temperaments. Evaluating breeding rams is part of the bigger picture of building stronger flocks — and we’re excited to share the process with you.

If you enjoy seeing how we evaluate our animals, follow along by subscribing to our channel. We share daily insights into the joys and challenges of sheep farming here in Canada.