Unique Structure Of African Swine Fever Virus Enzyme May Allow Drug Development

Mar 01, 2017

A DNA-copying protein from a lethal pig virus has a unique structure that may offer a target for drugs designed to combat this important agricultural disease, according to a study publishing February 28th in the open-access journal PLOS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China.

African swine fever virus (ASFV) is a highly contagious and deadly disease in pigs that has spread from Africa to areas of Europe and Asia. Currently there are no treatments, and control relies on killing entire herds once infection is detected. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, but the structure of this enzyme has not been determined in detail. Here, the authors used X-ray diffraction and nuclear magnetic resonance to solve the structure at atomic resolution.

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Video: Sow Welfare and Group Housing Systems - Dr. Laya Alves

In this episode of The Swine it Podcast Show Canada, Dr. Laya Alves from the University of São Paulo, in Brazil, discusses how animal welfare regulations are evolving globally and their impact on pig production systems. She explains challenges in group housing, pain management, and euthanasia decisions, while highlighting the role of training and management in improving outcomes and economic sustainability. Listen now on all major platforms!

"Translating welfare requirements into daily farm routines without compromising economic sustainability remains one of the biggest challenges faced by producers globally today."

Meet the guest: Dr. Laya Alves / laya-kannan is a Postdoctoral Researcher at the University of São Paulo, Brazil, focusing on animal welfare in pig production, including pain management, euthanasia, and economic decision making. Her work integrates welfare science with practical farm management and sustainability. She collaborates globally to develop applied tools for producers.