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Unique Structure Of African Swine Fever Virus Enzyme May Allow Drug Development

A DNA-copying protein from a lethal pig virus has a unique structure that may offer a target for drugs designed to combat this important agricultural disease, according to a study publishing February 28th in the open-access journal PLOS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China.



African swine fever virus (ASFV) is a highly contagious and deadly disease in pigs that has spread from Africa to areas of Europe and Asia. Currently there are no treatments, and control relies on killing entire herds once infection is detected. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, but the structure of this enzyme has not been determined in detail. Here, the authors used X-ray diffraction and nuclear magnetic resonance to solve the structure at atomic resolution.
 

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CEOs of the Industry: John McIntire, Partner at Pike Pig Systems

Video: CEOs of the Industry: John McIntire, Partner at Pike Pig Systems

CEOs of the Industry, Jim sits down with John McIntire, Partner at Pike Pig Systems, one of the most quietly impressive 26,000-sow operations in the U.S. John shares how he grew from operator to partner, how Pike built a people-first culture with long-tenured managers, and why they’re committed to weaning bigger, stronger pigs at 25+ days.

John breaks down how Pike stays efficient in a tough economic environment, the power of their shareholder-owned farm model, and how their work with PIC and a 240-head boar facility drives genetics and health outcomes. He also opens up about the innovations Pike adopts — and how they decide what’s truly valuable versus industry hype.

From Prop 12 and labor challenges to trade, consumer expectations, and sustainability, John chooses a hot-button issue and shares how Pike is preparing for the future. The episode closes with a rapid-fire “Fast Five” — mindset, leadership, daily habits, and three words that define Pike Pig Systems in 2025.

If you want a look inside a people-driven, purpose-driven, quietly elite pork system, this is an episode you won’t want to miss.