Unique Structure Of African Swine Fever Virus Enzyme May Allow Drug Development

Mar 01, 2017

A DNA-copying protein from a lethal pig virus has a unique structure that may offer a target for drugs designed to combat this important agricultural disease, according to a study publishing February 28th in the open-access journal PLOS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China.

African swine fever virus (ASFV) is a highly contagious and deadly disease in pigs that has spread from Africa to areas of Europe and Asia. Currently there are no treatments, and control relies on killing entire herds once infection is detected. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, but the structure of this enzyme has not been determined in detail. Here, the authors used X-ray diffraction and nuclear magnetic resonance to solve the structure at atomic resolution.

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Video: Industry–University Collaborations in Swine Research - Dr. Jordan Gebhardt and Matt Einarson

In this episode of The Swine it Podcast Show, Dr. Jordan Gebhardt from Kansas State University and Matt Einarson from SAM Nutrition explore how academic–industry partnerships are driving innovation in swine nutrition. They share how collaborations support graduate training, create credibility, and translate research into practical strategies for producers. Discover real trial outcomes, sustainability initiatives, and why bridging science with industry is essential for the future. Listen now on all major platforms!

"The partnership with universities allows research to stay current, answering real questions that nutritionists and producers are asking today." - Dr. Jordan Gebhardt

Meet the guest: Dr. Jordan Gebhardt / jordan-gebhardt-9a6b4b120 , Associate Professor of Swine Production at Kansas State University, combines expertise in veterinary medicine and applied swine nutrition to improve herd health and productivity through research and student training. Matt Einarson / matt-einarson-7a00a123 , Vice President of Sales and Business Development North America at SAM Nutrition, brings more than two decades of leadership in global agribusiness, specializing in strategy, market development, and feed innovation.